Road to measles elimination is predictable, but can be rocky

The United States has seen more measles cases so far in 2019 than in any year since elimination was declared in 2000 – meaning the disease is no longer endemic in the country, spreading constantly throughout the year. This year’s American outbreak is dwarfed by those in Ukraine, Philippines, Madagascar, the Democratic Republic of Congo , and Venezuela and Brazil, which have recorded tens of thousands of cases each. Measles symptoms include high fever and a full-body rash, and the infection can be fatal or limit the body’s ability to fight off other infections.

Each of these outbreaks is individually difficult to predict. But our research team has found that big year-to-year swings in the number of measles cases as a country approaches elimination are to be expected. By analyzing the patterns of measles outbreaks in Africa and the Americas since the 1980s, our multi-institution team of biologists and epidemiologists has identified a general pattern of measles infection over time as countries increase vaccination coverage and as birth rates decline.

Characterizing this trend, which we call the “canonical path to elimination,” means we can pinpoint the current positions of various countries along the path. Health policymakers can then prioritize where to focus, allocating appropriate solutions to help countries that either need to move farther down the path or simply hold on to their previous progress toward the end of measles.

What decades of data show

Though the measles vaccine was first licensed in 1963, how quickly it entered use has varied across the world. In 1978, the U.S. set a formal goal to eliminate measles, and since 2012 all World Health Organization regions have adopted goals for measles elimination.

At first, when a country begins to tackle the disease, the average number of cases decreases. At the same time, though, outbreaks become more variable from year to year. That is, one year might see almost no cases of the disease, while the following year has several hundred, or several thousand. This year-to-year variability is largest once the average number of cases drops below about five cases per 100,000 people in the population. Once a country hits that point, measles becomes both less common and less variable, signaling the final stages on the road to elimination.

Though they progress at different rates, countries tend to follow the ‘canonical path to elimantion.’ The number of measles cases initially declines while the year-to-year variability in outbreaks increases. Once a country turns the corner, measles cases are rare and the variability also decreases. Graham et al, Science Vol 364 Issue 6440, CC BY-ND
This general trend has important implications for countries on either side of that critical five cases per 100,000 tipping point.

Countries that haven’t yet reached that point, like DRC and Madagascar, can expect more variable outbreak dynamics as their vaccination programs continue to improve. Anticipating the likelihood of more variability year to year can help to plan appropriate contingency responses for when outbreaks do occur.

For countries that have already passed this tipping point, like the U.S. and Venezuela, backsliding vaccination rates will likely move the dynamics backwards on this canonical path. Rather than seeing a gradual increase in measles cases that would signal concern, these countries would first see a dramatic increase in the year-to-year variability in measles cases, with large outbreaks like the ones they’ve experienced in the last few years. That increased annual variability can be disruptive to public health systems since it requires dramatic shifts in funding and policies to contain outbreaks when they happen.

Moving along a known path

Identifying this general trend over time means that health policymakers now have a consistent way to identify where countries lie on the path to elimination, relative to the low measles/high variability tipping point. They can also see which direction countries are going – improving or backsliding – and how fast they’re moving. Notably, the path to elimination illustrates that as countries advance toward the tipping point we expect to see a slowdown in the rate of decline in average measles cases.

Looking to countries, and regions, that have moved quickly down the path to elimination can help public health officials identify policies that speed countries past the tipping point.