Platelets: The chameleons of cancer biology

Have you ever been in a classroom and wondered to yourself whether the information being presented could be wrong?

During graduate school, I audited a medical school class in which the professor remarked that at some point in the students’ medical training, a fact would be presented that later may be shown to be incorrect.

New discoveries are continuously upending our most fundamentally held dogmas. One area currently being reexamined is the complicated interactions between the components of blood with your body. Don’t worry; just like your high school textbook says, red blood cells still bring oxygen from the lungs to rest of the body, and white blood cells are still protecting your body from foreign invaders. However, the more subtle roles of blood, especially in diseases like cancer, are not fully understood.

I am a cell and molecular biologist, and my background in research began with studying changes within cells that cause cancer. My interest in cancer eventually led me to explore how tumors are supplied with adequate nutrition. One blood component continued to arise in literature, displaying an interesting and dynamic role after a person develops cancer: platelets.

Platelets and cancer

Platelets are the component of blood that springs into action when you get a paper cut or scrape your knee. The signals governing the recognition of a wound, and how to address healing, are quite complicated. However, under normal physiological conditions, these signals mediate a process called platelet activation, which results in healing the wound by closing broken blood vessels.

In addition to this well-known role, scientists have uncovered many other functions of platelets. In fact, an association between higher numbers of platelets and the progression of cancer has been recognized for nearly five decades. Platelet numbers are elevated in cancer patients, and studies have shown that platelet-mediated blood clots are associated with tumor cell metastasis.

That suggests that platelets may be linked to the spread of cancer to other parts of the body. But that may not be the only thing the platelets do for cancer.

Platelets, along with other cell types, release microparticles which respond to a variety of stimuli, including those which mediate platelet activation for wound healing.

While the mechanisms of microparticles are not completely understood, several studies have demonstrated they contain molecules that modulate which genes are turned on and off. Altering gene activity ultimately affects the production or turnover of proteins, which can cause a multitude of changes that affect health. Interestingly, microparticles contain molecules that have been shown to alter gene expression, and are associated with cancer progression.

That brings up an interesting question: Is it possible that platelets and the microparticles they release upon activation could also modulate cancer progression?